| Name | Coach | Sponsors |
| DBacks | London H. | First Take Communications |
| Indians | Webb M. | Town Hall |
| Reds | Scott G. | Cafe Deluxe |
| Red Sox | Dan B. | Chef Geoff's |
| Tigers | Brian B. | Hyde Park Communications |
| Yankees | John K. | ICF International |
| Place | Team | Win | Loss | Percent | Games Behind |
| 1 | Yankees | 9 | 2 | 81.8 | 0 |
| 2 | Tigers | 7 | 4 | 63.6 | 2 |
| 3t | DBacks | 5 | 6 | 45.5 | 3 |
| 3t | Reds | 5 | 6 | 45.5 | 3 |
| 5 | Red Sox | 4 | 6 | 40 | 4.5 |
| 6 | Indians | 2 | 7 | 22.2 | 6 |
All games are played at Friendship Field, #4.
Printable Majors Division Game Schedule for Spring 2008 (Adobe PDF)
| Regular Season | |
| Saturday, April 5 | |
| Results | |
| DBacks 4, at Reds 3 | |
| at Tigers 14, Yankees 2 | |
| Red Sox 8, at Indians 6 | |
| Saturday, April 12 | |
| Results | |
| DBacks 12, at Tigers 6 | |
| at Yankees 12, Indians 4 | |
| Reds 5, at Red Sox 3 | |
| Saturday, April 19 | |
| Results | |
| at Yankees 10, Reds 7 | |
| Red Sox 18, at DBacks 10 | |
| Tigers 6, at Indians 5 | |
| Sunday, April 20 - Challenger Division | |
| Majors Team | |
| Red Sox | |
| Wednesday, April 23 | |
| Result | |
| at Tigers 6, Reds 5 | |
| Saturday, April 26 | |
| Results | |
| Reds 16, at Indians 5 | |
| Yankees 12, at DBacks 2 | |
| Tigers 9, at Red Sox 8 | |
| Sunday, April 27 - Challenger Division | |
| Majors Team | |
| Reds | |
| Tuesday, April 29 | |
| Result | |
| Indians 7, at DBacks 4 | |
| Wednesday, April 30 | |
| Result | |
| Tigers 4, at Reds 3 | |
| Thursday, May 1 | |
| Result | |
| Yankees 8, Red Sox 7 | |
| Saturday, May 3 | |
| Results | |
| Indians 3, at Red Sox 1 | |
| at Yankees 13, Tigers 5 | |
| Reds 1, at DBacks 0 | Forfeit |
| Sunday, May 4 - Challenger Division | |
| Majors Team | |
| Yankees | |
| Tuesday, May 6 | |
| Result | |
| Tigers 12, at DBacks 9 | |
| Wednesday, May 7 | |
| Result | |
| Yankees 15, at Indians 9 | |
| Thursday, May 8 | |
| Result | |
| Red Sox 15, at Reds 1 | |
| Saturday, May 10 | |
| Teams | Time |
| Indians at Tigers | Cancelled |
| Red Sox at DBacks | Cancelled |
| Yankees at Reds | Cancelled |
| Sunday, May 11 - Challenger Division | |
| Majors Team | |
| Tigers | |
| Tuesday, May 13 | |
| Result | |
| at Tigers 8, Red Sox 7 | |
| Wednesday, May 14 | |
| Result | |
| at Reds 7, Indians 6 | |
| Thursday, May 15 | |
| Result | |
| at Yankees 1, DBacks 0 | Forfeit |
| Saturday, May 17 | |
| Results | |
| at Red Sox 8, Yankees 3 | |
| DBacks 17, at Indians 5 | |
| Sunday, May 18 - Challenger Division | |
| Majors Team | |
| Indians | |
| Tuesday, May 20 | |
| Result | |
| Red Sox 3, at Indians 3 | Suspended Game |
| Wednesday, May 21 | |
| Result | |
| DBacks 8, at Reds 2 | |
| Thursday, May 22 | |
| Result | |
| Yankees 1, at Tigers 0 | Forfeit |
| Saturday, May 24 | |
| All-Star Game | |
| Tuesday, May 27 | |
| Result | |
| DBacks 7, at Tigers 5 | |
| Wednesday, May 28 | |
| Result | |
| at Yankees 9, Indians 7 | |
| Thursday, May 29 | |
| Result | |
| Reds 11, at Red Sox 8 | |
| Saturday, May 31 | |
| Teams | Time |
| Reds at Yankees | Cancelled |
| Red Sox at DBacks | Cancelled |
| Tigers at Indians | Cancelled |
| Sunday, June 1 - Challenger Division | |
| Majors Team | |
| DBacks | |
| Playoffs | |
| Monday, June 2 | |
| Result | |
| at DBacks 9, Indians 7 | |
| Tuesday, June 3 | |
| Result | |
| at Reds 9, Red Sox 8 | |
| Wednesday, June 4 | |
| Result | |
| at Yankees 15, DBacks 3 | |
| Thursday, June 5 | |
| Result | |
| at Tigers 2, Reds 1 | |
| Championship Game | |
| Saturday, June 7 | |
| Result | |
| at Yankees 8, Tigers 7 | |